Biosimilars offer the potential for €2 billion of savings annually across the EU. To facilitate biosimilar uptake, several mechanisms aimed at reducing the acquisition cost of biosimilars and encouraging biosimilar uptake have been implemented. However, the mechanisms used vary across the EU and it is unclear which mechanisms contribute towards a sustainable biosimilar marketplace. Using publicly available information combined with stakeholder interviews across the EU5, a number of mechanisms were identified and assessed towards biosimilar sustainability.